The Impact of the COVID-19 Pandemic on Patients Diagnosed with Chronic Inflammatory Demyelinating Polyradiculoneuropathy – Three-Year Follow-Up
Authors
Keywords:
- COVID-19,
- CIDP,
- Psychological status,
- Pandemic,
- Stress
Abstract
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a neurological disorder characterized by autoimmune disruption of the peripheral nervous system, resulting in progressive weakness and sensory disturbance in the extremities. Following the COVID-19 pandemic, many illnesses demonstrated unpredictable progression due to infection with SARS-CoV-2. This study aimed to evaluate the impact of the pandemic on patients with CIDP over a three-year period. We conducted a prospective study on 11 adult CIDP patients, assessing muscle strength using the Medical Research Council (MRC) sum score, sensory symptoms and functional disability with the Inflammatory Neuropathy Cause and Treatment (INCAT) disability score and overall Quality of Life (QoL) through a numerical rating scale (0–100) supplemented by a COVID-19–specific questionnaire. Results showed that 55.1% of patients were concerned about the pandemic, primarily due to fears of relatives or friends being infected. Concerns regarding CIDP status included difficulties in drug availability, limited hospital access and possible worsening of clinical presentation due to comorbidities. QoL correlated with age (rho = –0.58, p < 0.01), MRC-SS at testing (rho = +0.44, p < 0.05) and INCAT disability score at testing (rho = –0.60, p < 0.01). Patients with greater fear of COVID-19 had significantly worse QoL compared to those with little or no fear (54.1 ± 16.9 vs. 70.3 ± 17.9, p < 0.05). Our findings suggest that the COVID-19 pandemic had a significant negative impact on patients with CIDP, with contributing factors including the direct effects of the virus, psychological distress and restrictive measures that worsened disease progression.
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References
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