Timedsurgical Mixed Peelings: Standardized High Frequency and Resorcinol Protocol for Rejuvenation and Pigmentation Correction (Video 1, Video 2-3)
Authors
Keywords:
- Timedsurgical mixed peeling,
- Resorcinol peeling,
- High frequency electrosurgery,
- De-epithelialization,
- Electroporo cosmesis,
- Hyperpigmentation correction,
- Facial rejuvenation,
- Physical-chemical synergy,
- Standardized peeling protocol,
- Lip wrinkles,
- Dark circle,
- Skin depigmentation,
- Erythrosis treatment,
- Giant scalp nevi treatment
Abstract
Background: Facial rejuvenation implies eliminating or reducing wrinkles and skin blemishes, if present. Lasers and chemical peels are used. These techniques are not standardized and can lead to incomplete outcomes: Recurrence of pigmentation, hypopigmentation, dark spots and unsatisfactory results
Objective: After testing various acids, phenols and lasers, we developed and perfected mixed peeling. This standardized technique combines a physical approach with resorcinol in an aqueous solution, aiming to achieve consistent and safe aesthetic outcomes.
Materials and Methods: Mixed peeling combines a single chemical agent, resorcinol, dissolved in water or in 3% hydrogen peroxide, with the physical action delivered via the TIMED TD 50 micropulse apparatus (Korpo), which delivers specific high frequency currents producing three effects: de epithelialization, epidermal permeabilization and Electroporo Cosmesis. Resorcinol, inactive on intact skin, becomes highly effective when applied after these physical actions.
Results: In 1334 patients treated between 2020 and 2025, mixed peeling improved skin texture and corrected lip wrinkles including deep ones in a single session. eliminated pigmentations, depigmented normal skin and even giant congenital melanocytic nevi of the scalp. No significant adverse events were observed. The same saturated or 50% solution produces strong, medium or light peels depending on the electrosurgical settings.
Conclusions: Timedsurgical mixed peelings represent a standardized, cost-efficient approach for facial rejuvenation and pigment correction. The combination of controlled physical action and targeted chemical action offers reproducible results with minimal downtime. In cases of hyperpigmentation, their ability to reduce melanocyte density contributes to long-lasting outcomes. Resorcinol, in contact with the dermis, has shown previously undocumented properties, which we have described in this report.
Downloads
References
Lee KC, Wambier CG, Soon SL, Sterling JB, Landau M, et al. (2019) Basic chemical peeling: Superficial and medium-depth peels. J Am Acad Dermatol. 81: 313-324. https://www.jaad.org/article/S0190-9622(18)33049-4/abstract
Harmon CB, Hadley M, Tristani P (2011) Trichloroacetic acid. In: Tosti A, Grimes P, De Padova M (eds) Color atlas of chemical peels. Springer, Berlin, Heidelberg. https://link.springer.com/chapter/10.1007/3-540-30223-9_7
Kitzmiller JW, Visscher M, Page DA, Wicket RR, Kitzmiller KW, et al. (2000) A controlled evaluation of dermabrasion versus CO2 laser resurfacing for the treatment of perioral wrinkles. Plast Reconstr Surg 106: 1366-1372. https://www.ovid.com/jnls/plasreconsurg/abstract/00006534-200011000-00024~a-controlled-evaluation-of-dermabrasion-versus-co2-laser?redirectionsource=fulltextview
Hernández-Pérez E, Edith C (1995) Resorcinol peels: Gross and microscopic study. The American Journal of Cosmetic Surgery 12: 337-340. https://journals.sagepub.com/doi/abs/10.1177/074880689501200410
De Oliveira CN, Bisson GB, Ferreira JO (2025) Adverse effects associated with the irresponsible use of phenol peeling: Literature review. Oral Surg Oral Med Oral Pathol Oral Radiol 139: 161-165. https://www.oooojournal.net/article/S2212-4403(24)00449-8/abstract
Capurro S, Hesse A, Toniutti F, Maello M (1986) Il diatermocauterio programmabile: Un nuovo strumento microchirurgico. Acta Chir Ital 42.
Capurro S, Fiallo P (1997) Epidermal de-epithelialization by programmed diathermosurgery. Dermatol Surg 23: 600-601. https://www.ovid.com/jnls/dermatologicsurgery/abstract/10.1111/j.1524-4725.1997.tb00705.x~epidermal-disepithelialization-by-programmed?redirectionsource=fulltextview
Capurro S, Pellegrini G (2002) Re-pigmentation of stable vitiligo of the face by means of timedsurgical de-epithelialisation and autologous grafts of cultivated epidermis. CRPUB Medical Video Journal. Timedsurgery section. https://crpub.org/timedsurgery/item/34-05-re-pigmentation-of-stable-vitiligo-of-the-face-by-means-of-timedsurgical-de-epithelialisation-and-autologous-grafts-of-cultivated-epidermis
Guerra L, Capurro S, Melchi F, Primavera G, Bondanza S, et al. (2000) Treatment of "stable" vitiligo by Timedsurgery and transplantation of cultured epidermal autografts. Arch Dermatol 136: 1380-1389. https://jamanetwork.com/journals/jamadermatology/fullarticle/190773
Mavilio F, Pellegrini G, Ferrari S, Di Nunzio F, Di Iorio E, et al. (2006) Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med 12: 1397-402. https://www.nature.com/articles/nm1504
Capurro S (2023) Elimination of roughness and festoons of the lower eyelid by means of mixed timedsurgical peeling. CRPUB Medical Video Journal. Elastic Plastic Surgery section. https://crpub.org/timedsurgery/item/144-28-elimination-of-roughness-and-festoons-of-the-lower-eyelid-by-means-of-mixed-timedsurgical-peeling
Capurro S (2019) Eliminating dark eye-rings with timedsurgical mixed peeling. https://crpub.org/timedsurgery/item/107-17-eliminating-dark-eye-rings-with-timedsurgical-mixed-peeling/
Capurro S (2023) Permanent elimination of lip wrinkles by means of mixed peeling while maintaining the integrity of a dermal nevus. Timedsurgery section. https://crpub.org/timedsurgery/item/145-29-permanent-elimination-of-lip-wrinkles-by-means-of-mixed-peeling-while-maintaining-the-integrity-of-a-dermal-nevus
Capurro S (2008) Removal of a dermal-epidermal patch on the face by means of timedsurgical mixed peeling. CRPUB Medical Video Journal. Timedsurgery section. https://crpub.org/timedsurgery/item/35-06-removal-of-a-dermal-epidermal-patch-on-the-face-by-means-of-timedsurgical-mixed-peeling
Capurro S (2022) Permanent depigmentation with timedsurgical mixed peeling of normal facial skin in vitiligo universalis. Timedsurgery section. https://crpub.org/timedsurgery/item/129-24-permanent-de-pigmentation-with-timedsurgical-mixed-peeling-of-normal-facial-skin-in-vitiligo-universalis
Capurro S (2022) Treatment-of-a-superficial-skin-angioma-of-the-face-with-electroporo-cosmesiseatment of a superficial skin angioma of the face with Electroporo Cosmesis. Timedsurgery section. https://crpub.org/timedsurgery/item/130-25-treatment-of-a-superficial-skin-angioma-of-the-face-with-electroporo-cosmesis
Capurro S (2022) Elimination of facial hyperpigmentation by means of Electroporo Cosmesis and 0.5 mixed peeling. Timedsurgery section. https://crpub.org/timedsurgery/item/127-23-elimination-of-facial-hyperpigmentation-by-means-of-electroporo-cosmesis-and-0-5-mixed-peeling
Capurro S (2025) Treatment of penile melanosis with Timedsurgical mixed peeling 0.5: Case Report. J Surg Med Case Rep 2: 1-4. https://scholar.google.com/scholar?cluster=17723012473813407100&hl=en&as_sdt=0,5
